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Comparative Cost-Effectiveness of Hypertension Treatment in Non-Hispanic Blacks and Whites According to 2014
Eshan Vasudeva1, Nathalie Moise2, Chen Huang3
1College of Physicians and Surgeons, Columbia University, New York, USA;
Insights
Implementing 2014 US hypertension guidelines is cost-effective for both Black and White adults. However, the guidelines extend cost-effectiveness to a larger proportion of Black patients, particularly younger individuals with stage 1 hypertension.
Area of Science:
- Public Health
- Health Economics
- Cardiovascular Disease Prevention
Background:
- Hypertension treatment guidelines aim to reduce cardiovascular disease (CVD) events.
- Cost-effectiveness of these guidelines may vary across different demographic groups.
Purpose of the Study:
- To compare the cost-effectiveness of 2014 US hypertension treatment guidelines between non-Hispanic Black and non-Hispanic White adults.
- To identify specific subgroups where guideline implementation is most cost-effective.
Main Methods:
- A cardiovascular disease (CVD) policy model simulated CVD events, quality-adjusted life years (QALYs), and treatment costs in adults aged 35-74 with untreated hypertension.
- Data on CVD incidence, mortality, and risk factors were sourced from cohort studies, registries, vital statistics, and national surveys.
- Cost-effectiveness was determined using incremental cost-effectiveness ratios (ICERs), with <$50,000/QALY gained considered cost-effective.
Main Results:
- Overall 2014 guideline implementation was cost-saving compared to no treatment for both non-Hispanic Black and White populations.
- Treating 0.7 million hypertensive Black adults could prevent ~8,000 CVD events annually; treating 3.4 million White adults could prevent ~35,000 events.
- For stage 1 hypertension without diabetes or CKD, cost-effectiveness extended to younger Black males and females (ages 35-44) but not their White counterparts.
Conclusions:
- Implementing 2014 US hypertension guidelines is cost-effective for both non-Hispanic Black and White populations.
- The cost-effectiveness of these hypertension guidelines extends to a larger proportion of non-Hispanic Black patients compared to non-Hispanic White patients.
Background:
We compared the cost-effectiveness of hypertension treatment in non-Hispanic blacks and non-Hispanic whites according to 2014 US hypertension treatment guidelines.
Methods:
The cardiovascular disease (CVD) policy model simulated CVD events, quality-adjusted life years (QALYs), and treatment costs in 35- to 74-year-old adults with untreated hypertension. CVD incidence, mortality, and risk factor levels were obtained from cohort studies, hospital registries, vital statistics, and national surveys. Stage 1 hypertension was defined as blood pressure 140-149/90-99mm Hg; stage 2 hypertension as ≥150/100mm Hg. Probabilistic input distribution sampling informed 95% uncertainty intervals (UIs). Incremental cost-effectiveness ratios (ICERs) < $50,000/QALY gained were considered cost-effective.
Results:
Treating 0.7 million hypertensive non-Hispanic black adults would prevent about 8,000 CVD events annually; treating 3.4 million non-Hispanic whites would prevent about 35,000 events. Overall 2014 guideline implementation would be cost saving in both groups compared with no treatment. For stage 1 hypertension but without diabetes or chronic kidney disease, cost savings extended to non-Hispanic black males ages 35-44 but not same-aged non-Hispanic white males (ICER $57,000/QALY; 95% UI $15,000-$100,000) and cost-effectiveness extended to non-Hispanic black females ages 35-44 (ICER $46,000/QALY; $17,000-$76,000) but not same-aged non-Hispanic white females (ICER $181,000/QALY; $111,000-$235,000).
Conclusions:
Compared with non-Hispanic whites, cost-effectiveness of implementing hypertension guidelines would extend to a larger proportion of non-Hispanic black hypertensive patients.
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