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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
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Ischemic Preconditioning Enhances Muscle Endurance during Sustained Isometric Exercise.

D Tanaka1, T Suga1, T Tanaka1

  • 1Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.

International Journal of Sports Medicine
|May 14, 2016
PubMed
Summary
This summary is machine-generated.

Ischemic preconditioning (IPC) improves exercise endurance by enhancing skeletal muscle metabolism. This study shows IPC accelerates muscle deoxygenation, suggesting improved mitochondrial function contributes to better performance.

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Area of Science:

  • Exercise Physiology
  • Skeletal Muscle Physiology
  • Mitochondrial Metabolism

Background:

  • Ischemic preconditioning (IPC) is known to improve whole-body exercise endurance.
  • The precise mechanisms, whether systemic or peripheral, remain unclear.
  • Investigating IPC's effect on local skeletal muscle adaptations is crucial.

Purpose of the Study:

  • To determine the impact of IPC on local muscle endurance during fatiguing isometric exercise.
  • To explore the underlying physiological changes in skeletal muscle following IPC.
  • To differentiate between systemic and peripheral contributions to IPC's benefits.

Main Methods:

  • 12 male subjects performed unilateral knee-extension exercise to failure.
  • Subjects underwent either IPC or control (CON) treatment prior to exercise.
  • Muscle electromyography (EMG) and near-infrared spectroscopy (NIRS) were used to assess muscle activity and deoxygenation.

Main Results:

  • IPC significantly increased endurance time to task failure compared to CON (233±9s vs. 198±9s).
  • No significant difference in quadriceps EMG activity was observed between IPC and CON.
  • IPC accelerated deoxygenation dynamics in the vastus lateralis muscle (27.1±3.4s vs. 35.0±3.6s).

Conclusions:

  • IPC enhances muscular endurance during fatiguing isometric exercise.
  • IPC accelerates muscle deoxygenation, indicating improved oxygen utilization.
  • Enhanced mitochondrial metabolism in skeletal muscle is suggested as the origin of IPC's performance benefits.