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Updated: Mar 21, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

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Skin manifestations associated with kidney cancer

Asim Amin1, Earle F Burgess1

  • 1Levine Cancer Institute at Carolinas Medical Center, Charlotte, NC.

Seminars in Oncology
|May 15, 2016
PubMed

Insights

Recognizing skin manifestations is crucial for early kidney cancer detection, especially in hereditary syndromes like Von Hippel-Lindau and Birt-Hogg-Dubé. Prompt identification of these cutaneous signs aids in managing renal cell carcinoma (RCC).

Area of Science:

  • Oncology
  • Dermatology
  • Genetics

Background:

  • Kidney cancer, specifically renal cell carcinoma (RCC), is a complex disease with varied molecular and clinical profiles.
  • Immunologic responses can influence the course and presentation of RCC.
  • Atypical disease presentations, including skin manifestations, require careful recognition.

Purpose of the Study:

  • To review the clinical presentation of skin metastases from RCC.
  • To discuss hereditary syndromes associated with increased RCC risk and their characteristic skin lesions.
  • To briefly cover dermatologic toxicities of immunomodulatory treatments for advanced RCC.

Main Methods:

  • Literature review focusing on cutaneous manifestations of RCC.
  • Discussion of hereditary syndromes (Von Hippel-Lindau, Birt-Hogg-Dubé) linked to RCC.
  • Brief overview of immunomodulatory therapies and their dermatologic side effects.

Main Results:

  • Skin metastases from RCC are rare but clinically significant.
  • Hereditary syndromes like Von Hippel-Lindau and Birt-Hogg-Dubé present with distinct skin lesions and predispose to RCC.
  • Cutaneous lesions can be the initial indicator of underlying RCC, necessitating timely recognition.

Conclusions:

  • Timely recognition of cutaneous manifestations is essential for early diagnosis and management of renal cell carcinoma.
  • Understanding the link between specific hereditary syndromes and RCC is critical for risk assessment.
  • Awareness of dermatologic toxicities is important for patients undergoing immunotherapy for advanced RCC.
Keywords:
Birt-Hogg-Dubé syndromeHereditary leiomyomatosis and renal cell carcinomaRenal cell carcinomaVon Hippel-Lindau

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