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Catalytic antibodies with lipase activity and R or S substrate selectivity
K D Janda1, S J Benkovic, R A Lerner
1Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
Science (New York, N.Y.)
|April 28, 1989
Abstract:
The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (10(3) to 10(5] above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.