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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
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[Hepatitis B and pregnancy. Part 2. Nine practical issues about delivery and neonatal care]

A Fouquet1, A-C Jambon2, V Canva3

  • 1Université Nord-de-France, hôpital Jeanne-de-Flandre, CHRU de Lille, 1, rue Eugène-Avinée, 59037 Lille cedex, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|May 17, 2016
PubMed

Insights

Hepatitis B serovaccination at birth, including immunoglobulins and vaccines, significantly reduces mother-to-child transmission from 57% to 4%. High maternal viral load and HBeAg presence are key risk factors for failure.

Area of Science:

  • Hepatology
  • Immunology
  • Public Health

Background:

  • Hepatitis B poses a significant risk of mother-to-child transmission.
  • Current prevention strategies in France focus on serovaccination at birth.

Purpose of the Study:

  • To evaluate the effectiveness of the French hepatitis B maternal-fetal transmission prevention strategy.
  • To identify risk factors associated with serovaccination failure.

Main Methods:

  • Serovaccination protocol involving anti-HBs immunoglobulins and hepatitis B vaccine at birth.
  • Follow-up vaccination schedule at 1 and 6 months, with an additional dose for premature or low-birth-weight infants.
  • Analysis of risk factors including maternal viral load and HBeAg status.

Main Results:

  • Serovaccination at birth reduces transmission risk from 57% to 4%.
  • High maternal viral load (≥7 log) and/or HBeAg presence are identified as failure risk factors.
  • Delivery route and breastfeeding do not significantly alter transmission risk when serovaccination is properly administered.

Conclusions:

  • The implemented serovaccination strategy is highly effective in preventing hepatitis B mother-to-child transmission.
  • Monitoring maternal viral load and HBeAg status is crucial for identifying high-risk pregnancies.
  • WHO recommends this serovaccination approach.

Keywords:
AllaitementBreastfeedingDelivery routeGrossesseHepatitis BHépatite BMaterno-fetal transmissionPregnancyPreventionPréventionTransmission materno-fœtaleVoie d’accouchement

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