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Late Metabolic Acidosis Caused by Renal Tubular Acidosis in Acute Salicylate Poisoning
Norihiro Sakai1, Yasuo Hirose, Nobuhiro Sato
1The Department of Emergency and Critical Care Medicine, Niigata City General Hospital, Japan.
Abstract:
A 16-year-old man was transferred to our emergency department seven hours after ingesting 486 aspirin tablets. His blood salicylate level was 83.7 mg/dL. He was treated with fluid resuscitation and sodium bicarbonate infusion, and his condition gradually improved, with a decline in the blood salicylate level. However, eight days after admission, he again reported nausea, a venous blood gas revealed metabolic acidosis with a normal anion gap. The blood salicylate level was undetectable, and a urinalysis showed glycosuria, proteinuria and elevated beta-2 microglobulin and n-acetyl glucosamine levels, with a normal urinary pH despite the acidosis. We diagnosed him with relapse of metabolic acidosis caused by renal tubular acidosis.
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