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Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
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Diabetic Macular Edema.

Fatih C Gundogan1, Umit Yolcu2, Fahrettin Akay3

  • 1Fatih C. Gundogan, GATA Medical School, Ophthalmology, Ankara, Turkey.

Pakistan Journal of Medical Sciences
|May 17, 2016
PubMed
Summary
This summary is machine-generated.

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Diabetic macular edema (DME) is a leading cause of vision loss. Current treatments offer temporary relief, highlighting the urgent need for more effective, long-term therapeutic options for diabetic patients.

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Medical Imaging

Background:

  • Diabetic macular edema (DME) is a significant cause of vision impairment globally.
  • It can occur at any stage of diabetic retinopathy.
  • Advances in fundus imaging, like optical coherence tomography, have improved DME diagnosis and management.

Purpose of the Study:

  • To review current diagnostic and treatment modalities for DME.
  • To identify the limitations of existing treatments.
  • To emphasize the need for novel, permanent treatment strategies for DME.

Main Methods:

  • Comprehensive literature search of major databases.
  • Selection of 40 relevant articles published between 1985 and 2015.
  • Review article synthesizing existing knowledge on DME.
Keywords:
BevacizumabDiabetic macular edemaFluorescein angiographyOptical coherence tomographyPars plana vitrectomyRanibizumabTriamcinolone acetonide

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Main Results:

  • Diagnosis and follow-up of DME are facilitated by modern imaging techniques.
  • Current treatments include laser photocoagulation, intravitreal injections, and vitrectomy.
  • The efficacy of current intravitreal agents is temporary.

Conclusions:

  • Existing treatments for DME provide only short-term benefits.
  • There is a critical need for the development of new treatments offering a permanent solution for DME.
  • Further research is essential to address the unmet needs in DME management.