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A model to determine required pool size for HLA-typed community donor apheresis programs
D C Bolgiano1, E B Larson, S J Slichter
1Puget Sound Blood Center, University of Washington School of Medicine, Seattle.
Transfusion
|May 1, 1989
Summary
Community plateletpheresis programs need sufficient HLA-typed donors for alloimmunized patients. Donor pool size models estimate 1000-3000 donors can meet most transfusion needs with B2 or better HLA matching.
Area of Science:
- Transfusion Medicine
- Immunogenetics
- Hematology
Background:
- Alloimmunized patients require HLA-matched platelet transfusions.
- Community donor programs face challenges in meeting these specific needs.
- Accurate donor pool sizing is critical for program sustainability.
Purpose of the Study:
- To develop a model for determining optimal community donor plateletpheresis program size.
- To estimate the average number of HLA-typed donors required per alloimmunized patient.
- To assess the adequacy of various donor pool sizes for meeting transfusion demands.
Main Methods:
- Retrospective analysis of 4338 plateletpheresis transfusions from 591 patients and up to 870 donors over 3 years.
- Development of a donor pool size model incorporating patient/donor HLA frequencies and compatibility levels.
- Validation of donor need estimates using real-world transfusion data.
Main Results:
- The average number of donors needed per patient ranged from 4 to 33.
- The developed model was applied to illustrate pool size determination.
- Model results indicate that 1000–3000 donors are sufficient for most patients at HLA-match grade B2 or better.
Conclusions:
- Community donor programs require robust HLA-typed donor pools to support alloimmunized patients.
- The developed model provides a framework for calculating appropriate donor pool sizes.
- Adequate donor pool sizes are essential for ensuring consistent availability of HLA-matched platelets.