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One-pot fabricating Fe3O4/graphene nanocomposite with excellent biocompatibility and non-toxicity as a negative MR
Ping Zan1, Chunyan Yang2, Huan Sun2
1Key Laboratory of Automobile Materials, Ministry of Education and School of Materials Science and Engineering, Jilin University, Changchun 130022, China.
Abstract:
We report a facile approach to synthesize water-dispersible nanocomposite with Fe3O4 nanoparticles (NPs) attached to graphene (G), which combines the growth of Fe3O4NPs and the reduction of graphene oxide (GO) in one single step. The unique hydrophilic surface structure of Fe3O4/G nanocomposite leads to it being colloidally stable, non-cytotoxic, well-dispersible and biocompatible in aqueous solution verified via bio-experiments. In vivo tests also prove that Fe3O4/G nanocomposite, which can be cleared from the body through the metabolic processes, is harmless to the living body. Most importantly, the Fe3O4/G nanocomposite showed T2relaxivity (123.04mM(-1)s(-1)) indicating its potential as a sensitive T2 contrast agent.
