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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Related Experiment Video

Updated: Mar 21, 2026

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
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Metabolic drift in the aging brain.

Julijana Ivanisevic1, Kelly L Stauch2, Michael Petrascheck3

  • 1Metabolomics Research Platform, University of Lausanne, 1005 Lausanne, Switzerland.

Aging
|May 17, 2016
PubMed
Summary
This summary is machine-generated.

Aging brains exhibit significant energy metabolic drift, characterized by compromised cellular energy status and altered metabolic pathways. This imbalance impairs the brain

Keywords:
energy metabolismhealthy brain agingmetabolic driftmetabolomicsproteomics

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Area of Science:

  • Neuroscience
  • Metabolomics
  • Aging Research

Background:

  • Cognitive impairments in aging are linked to disrupted brain energy metabolism.
  • Understanding metabolic homeostasis in the aging brain is crucial but poorly understood.

Purpose of the Study:

  • To investigate global metabolic and proteomic changes in the aging mouse brain across different lifespan stages.
  • To identify key metabolic alterations contributing to age-related cognitive decline.

Main Methods:

  • Global untargeted metabolomic and proteomic analyses.
  • Examination of different anatomical regions in mouse brains at various adult lifespan stages.

Main Results:

  • Aged mouse brains showed significant energy-metabolic drift and core metabolite imbalance, despite absent severe proteomic imbalance.
  • Key findings include NAD decline, increased AMP/ATP ratio, purine/pyrimidine accumulation, and altered oxidative phosphorylation and nucleotide metabolism.
  • Metabolic imbalance indicates a failure to restore metabolite homeostasis (metabostasis) in the aged brain.

Conclusions:

  • The aging brain struggles to maintain metabolic homeostasis, impacting cellular energy status.
  • This metabolic drift likely drives altered neuronal signaling, affecting brain function and communication.
  • Findings suggest a critical role for metabolic dysfunction in age-related cognitive impairments.