[THE CONTENT OF ELECTROLYTES IN DIFFERENT BIOLOGICAL MEDIUMS UNDER ACUTE CORONARY SYNDROME]
Insights
Electrolyte levels in blood and saliva differ between acute coronary syndrome and stable angina patients. Saliva analysis may offer insights into electrolyte imbalances in ischemic heart disease.
Area of Science:
- Cardiology
- Biochemistry
- Clinical Diagnostics
Context:
- Ischemic heart disease (IHD) encompasses conditions like acute coronary syndrome (ACS) and stable angina (SA).
- Electrolyte balance (calcium, sodium, potassium) is crucial for cardiovascular function.
- Non-invasive biomarkers for IHD assessment are of significant clinical interest.
Purpose:
- To investigate and compare the concentrations of calcium, sodium, and potassium in both blood and saliva.
- To determine if electrolyte distribution coefficients (blood/saliva) differ between ACS and SA patients.
- To explore the potential of saliva as a diagnostic fluid for electrolyte disturbances in IHD.
Summary:
- A study involving 172 ischemic heart disease patients (146 ACS, 26 SA) analyzed blood and saliva electrolyte levels.
- Patients with acute coronary syndrome exhibited lower blood calcium and sodium, but higher saliva calcium and potassium compared to stable angina patients.
- Distribution coefficients (blood/saliva) for electrolytes were notably higher in myocardial infarction cases than unstable angina.
Impact:
- Findings suggest distinct electrolyte profiles in blood and saliva associated with different IHD states.
- Saliva electrolyte analysis presents a potential non-invasive method for assessing electrolyte imbalances in IHD.
- This research could inform novel diagnostic strategies and personalized treatment approaches for cardiovascular patients.
Abstract:
The sampling of study included 172 patients with ischemic heart disease: 146 with acute coronary syndrome, including myocardial infarction (88 patients) and unstable stenocardia (58 patients); 26 patients with stable stenocardia functional class II-III. At the 1-3 day of hospitalization blood was taken of cubital vein. The mixed unstimulated saliva was selected. In both of them conte of calcium, sodium and potassium was tested (mmol/l). Under acute coronary syndrome, in blood content of calcium was 2. sodium--139.6 and potassium--4.5 i.e. the content was lower than in case of stable stenocardia (2.4; 139.8; 4.7 correspondingl In saliva under acute coronary syndrome higher content of calcium (1.05) and potassium (34.66) and lower content of sodiu (25.42) was established in comparison with stable stenocardia (0.81; 33.7; 28.08 correspondingly). The distribution coefficien (blood/saliva) of calcium, sodium and potassium were higher under myocardium infarction than under unstable stenocardia at uncomplicated course of acute coronary syndrome.
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