Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ureters01:22

Ureters

2.0K
The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
2.0K
Anatomy of the Genitourinary System I: Kidneys and Ureters01:11

Anatomy of the Genitourinary System I: Kidneys and Ureters

967
The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...
967
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

4.3K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
4.3K
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

783
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
783
Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

748
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
748
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion01:22

Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

1.9K
The kidneys maintain homeostasis through filtration, reabsorption, and secretion. Tubular reabsorption and secretion are crucial in forming urine and regulating electrolytes, water balance, and waste elimination.Tubular Reabsorption and Secretion ProcessesTubular reabsorption is the process that reclaims essential substances such as electrolytes, glucose, amino acids, and water from the glomerular filtrate back into the bloodstream. This is achieved through passive and active transport...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-Use vs Reusable Catheters for Intermittent Catheterization in Patients With Urinary Retention: The COMPARE Randomized Clinical Trial.

JAMA network open·2026
Same author

European Reference Networks as core health structures where referring genetic newborn screening positive infants: an innovative operational research framework.

Frontiers in public health·2026
Same author

Increased mTOR signaling secondary to a human ILK missense variant inhibits nephrogenesis with decreased metabolism.

Mechanisms of ageing and development·2025
Same author

Efficacy of combined targeted radionuclide therapy and immune checkpoint Inhibition in animal tumour models: a systematic review and meta-analysis of the literature.

European journal of nuclear medicine and molecular imaging·2025
Same author

International validation of a pre-transplant risk assessment tool for graft survival in pediatric kidney transplant recipients.

Clinical kidney journal·2025
Same author

Hyaluronic acid: Function and location in the urothelial barrier for bladder pain syndrome/interstitial cystitis, an in vitro study.

PloS one·2025
Same journal

On the Memoryless Property in Markov Models for NMIBC Cost-Effectiveness Analysis.

The Journal of urology·2026
Same journal

Multi-institutional Assessment of Performance Metrics for MRI-targeted Transperineal Prostate Biopsy.

The Journal of urology·2026
Same journal

Urinary Supersaturation in a Randomized Trial among Individuals with Recurrent Nephrolithiasis comparing Empiric versus Selective Preventive Therapy: The URINE Trial.

The Journal of urology·2026
Same journal

The FDA Should Allow More BCG Strains into the US Market: How Recent Landmark Trials Expose a Regulatory Paradox.

The Journal of urology·2026
Same journal

Let's Shift the Focus from Death to Life after Fournier's Gangrene.

The Journal of urology·2026
Same journal

Endourology and Nephrolithiasis.

The Journal of urology·2026
See all related articles

Related Experiment Video

Updated: Mar 21, 2026

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
04:05

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Published on: July 5, 2024

807

Tubular Constructs as Artificial Urinary Conduits.

Marije Sloff1, Vasileios Simaioforidis1, Dorien M Tiemessen1

  • 1Department of Urology, Radboud Institute for Molecular Life Sciences and Amalia's Children Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.

The Journal of Urology
|May 18, 2016
PubMed
Summary
This summary is machine-generated.

Subcutaneous pre-implantation of reinforced collagen constructs created a vascularized tube, potentially replacing bowel for urinary diversions. This two-step method shows promise for artificial urinary conduits.

Keywords:
collagen type 1polyglactin 910regenerative medicinetissue engineeringurinary diversion

More Related Videos

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.9K
Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

8.0K

Related Experiment Videos

Last Updated: Mar 21, 2026

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
04:05

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Published on: July 5, 2024

807
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.9K
Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

8.0K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Autologous bowel substitution in urinary diversions can cause complications.
  • Large artificial urinary conduits face challenges with cellular ingrowth and vascularization.
  • Collagen-based tubular constructs offer a potential alternative.

Purpose of the Study:

  • To investigate large, reinforced, collagen-based tubular constructs for urinary diversion in a porcine model.
  • To compare subcutaneously pre-implanted constructs with cell-seeded and basic constructs.
  • To assess the feasibility of artificial urinary conduits as a bowel substitute.

Main Methods:

  • Reinforced tubular constructs were fabricated from type I collagen and Vicryl® meshes.
  • Artificial urinary conduits were created in 17 pigs using basic, cell-seeded, or pre-implanted constructs.
  • Constructs were evaluated after 1 month for patency, vascularization, and tissue regeneration.

Main Results:

  • Pre-implantation of basic constructs resulted in a vascularized tissue tube, suitable for free grafting.
  • Urinary flow was maintained in all pre-implanted conduit groups, with better drainage and limited hydroureteronephrosis.
  • Cell-seeded and basic conduits showed occlusion in some cases, while pre-implanted constructs demonstrated improved tissue regeneration.

Conclusions:

  • Subcutaneous pre-implantation of reinforced tubular constructs yields a vascularized autologous tube for urinary diversion.
  • This method offers a promising, straightforward two-step procedure for creating artificial urinary conduits.
  • The pre-implanted construct approach may serve as a viable alternative to bowel segments in urinary diversion surgeries.