Transient neuronal coactivations embedded in globally propagating waves underlie resting-state functional
Teppei Matsui1, Tomonari Murakami2, Kenichi Ohki3
1Department of Molecular Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Department of Physiology, The University of Tokyo School of Medicine, Tokyo 113-0033, Japan; tematsui@m.u-tokyo.ac.jp kohki@m.u-tokyo.ac.jp.
Global brain waves coordinate localized neuronal activity, which is then reflected in resting-state functional connectivity (FC) measured by hemodynamic signals (HemoS). This study reveals how neuronal dynamics shape Hemo-FC patterns.
Area of Science:
- Neuroscience
- Systems Neuroscience
- Computational Neuroscience
Background:
- Resting-state functional connectivity (FC) noninvasively studies brain networks using hemodynamic signals (HemoS).
- It is assumed HemoS-based FC reflects underlying neuronal activity dynamics.
- The relationship between different large-scale neuronal dynamics and their contribution to Hemo-FC remains unclear.
Purpose of the Study:
- To investigate the interrelation between different large-scale spontaneous neuronal activities.
- To determine if these dynamics contribute to Hemo-FC.
- To elucidate the mechanisms linking neuronal activity to Hemo-FC.
Main Methods:
- Simultaneous monitoring of neuronal calcium signals (CaS) and HemoS in mouse neocortex.
- High spatiotemporal resolution imaging.
- Analysis of global waves and transient coactivations in relation to FC.
Main Results:
- A significant relationship was found between global neocortical waves and transient coactivations in areas with high FC.
- Cortical areas with high FC were coactivated at different phases of global waves, embedding network information.
- Neuronal coactivations (CaS) translate to HemoS coactivations, sustaining Hemo-FC spatial structure.
Conclusions:
- Global waves of spontaneous neuronal activity propagate across the neocortex.
- These waves contain spatial information about cortical networks characterized by FC.
- Transient neuronal coactivations during waves are crucial for generating Hemo-FC patterns during rest.
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