Vaccination against hepatitis A and B in patients with chronic liver disease and type 2 diabetes: has anything

Related Experiment Video

Updated: Mar 21, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

7.5K

Aaron Koenig1, Maria Stepanova1, Sean Felix1,2

  • 1Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA, USA.

Liver International : Official Journal of the International Association for the Study of the Liver
|May 18, 2016
PubMed

Insights

Hepatitis A (HAV) and B (HBV) vaccination rates increased in the general US population but remain low in patients with chronic liver disease (CLD) and type 2 diabetes (DM). Improved vaccination strategies are needed for these high-risk groups.

Area of Science:

  • Hepatology
  • Immunology
  • Public Health

Background:

  • Patients with chronic liver disease (CLD) and type 2 diabetes (DM) face severe risks from acute hepatitis.
  • Vaccination against Hepatitis A (HAV) and Hepatitis B (HBV) is recommended for these high-risk populations.

Purpose of the Study:

  • To assess recent trends in HAV and HBV vaccination rates.
  • To analyze vaccination coverage in US patients with CLD and DM using population data.

Main Methods:

  • Utilized National Health and Nutrition Examination Surveys (NHANES) data from 1999-2014.
  • Compared vaccination rates across different population subgroups and time periods.

Main Results:

  • HBV vaccination rates increased from 24.4% to 41.3% and HAV vaccination rates from 12.0% to 33.4% in the general US population (1999-2014).
  • Significant increases in HBV vaccination were observed in CLD patients (22.7% to 51.1%).
  • Vaccination rates in DM patients showed similar increases to the general population, despite recommendations.

Conclusions:

  • HAV and HBV vaccination coverage remains suboptimal in patients with CLD and DM.
  • There is a critical need for enhanced vaccination strategies targeting these vulnerable populations.
Abstract

Keywords:
HAVHBVdiabetesvaccination

More Related Videos

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.5K
Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

3.5K

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
7
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.4K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.9K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.4K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K
Vaccinations01:51

Vaccinations

Overview
53.4K