Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parathyroid function in Paget's disease of bone.

E S Siris1, T P Clemens, D McMahon

  • 1Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|February 1, 1989
PubMed
Summary

Secondary hyperparathyroidism affects 18% of Paget's disease patients with normal calcium. Elevated parathyroid hormone (PTH) correlates with disease severity, not calcium levels, suggesting increased bone formation demands.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stillbirth prevention: the challenges of public campaigns.

BJOG : an international journal of obstetrics and gynaecology·2017
Same author

Prevalence and predictors of early gestational weight gain associated with obesity risk in a diverse Australian antenatal population: a cross-sectional study.

BMC pregnancy and childbirth·2017
Same author

False-positive synovial fluid alpha-defensin test in a patient with acute gout affecting a prosthetic knee.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2017
Same author

Rural habitat as risk factor for hepatitis E virus seroconversion in HIV-infected patients: A prospective longitudinal study.

Zoonoses and public health·2017
Same author

EBRA-Digital release 2003 versus 1998: A comparison of instrument repeatability for measuring implant migration and wear.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2017
Same author

Differences in Gut Metabolites and Microbial Composition and Functions between Egyptian and U.S. Children Are Consistent with Their Diets.

mSystems·2017

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Biochemistry

Background:

  • Paget's disease of bone is a chronic disorder characterized by abnormal bone remodeling.
  • Secondary hyperparathyroidism is a potential complication, but its prevalence in Paget's disease is not well-established.

Purpose of the Study:

  • To determine the prevalence of secondary hyperparathyroidism in patients with Paget's disease of bone.
  • To investigate the relationship between parathyroid hormone levels and markers of disease activity.

Main Methods:

  • Measured serum parathyroid hormone (PTH) levels using an N-terminal assay in 39 patients with Paget's disease.
  • Assessed serum calcium, alkaline phosphatase, plasma bone Gla protein, and 24-hour urinary hydroxyproline.
  • Analyzed correlations between PTH and biochemical indices.

Related Experiment Videos

Main Results:

  • 18% (7 of 39) of patients exhibited elevated PTH levels.
  • Increased PTH correlated significantly with serum alkaline phosphatase, plasma bone Gla protein, and urinary hydroxyproline.
  • No correlation was found between PTH and serum calcium levels.

Conclusions:

  • Secondary hyperparathyroidism can occur in Paget's disease, particularly in more active cases.
  • Elevated PTH may be linked to increased calcium demands during heightened pagetic bone formation.
  • PTH levels are associated with disease severity rather than serum calcium concentration.