Topical Review: Mind Your Language-Translation Matters (A Narrative Review of Translation Challenges)

Jennifer S H Kiing1, Dimple Rajgor2, Teck-Hock Toh3

  • 1Khoo Teck Puat National University Children's Medical Institute, National University Health System, Singapore Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore jennifer_kiing@nuhs.edu.sg.

Abstract

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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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