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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Programmable biomaterials for dynamic and responsive drug delivery.

Anna Stejskalová1, Mehrdad T Kiani1, Benjamin D Almquist2

  • 1Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.

Experimental Biology and Medicine (Maywood, N.J.)
|May 19, 2016
PubMed
Summary

Researchers are programming advanced biomaterials for dynamic drug delivery, enhancing treatments for cancer and infections by coordinating multiple therapeutics and responding to tissue changes.

Keywords:
Bionanosciencebacteriabiomaterialscancerdrug deliverynanoparticles

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Area of Science:

  • Biomaterials science and engineering
  • Drug delivery systems
  • Regenerative medicine

Background:

  • Biomaterials are crucial for dynamic interactions with cells and tissues.
  • These interactions unlock new capabilities in drug delivery and regenerative medicine.
  • Recent advances focus on programming biomaterials for enhanced therapeutic applications.

Purpose of the Study:

  • To review recent advances in programming biomaterials for improved drug delivery.
  • To focus on applications in cancer and infection treatment.
  • To explain underlying concepts and examine recent material systems.

Main Methods:

  • Explaining fundamental concepts in designing advanced drug delivery vehicles.
  • Examining material systems capable of temporal delivery of multiple therapeutics.
  • Analyzing biomaterials that dynamically respond to changing tissue environments.
  • Investigating materials that can reprogram bioactivity over time.

Main Results:

  • Novel biomaterial systems demonstrate coordinated temporal delivery of multiple therapeutics.
  • Materials exhibit dynamic responsiveness to evolving tissue microenvironments.
  • Biomaterials show the ability to reprogram their bioactivity over extended periods.
  • These advancements offer improved strategies for cancer and infection treatment.

Conclusions:

  • Programming biomaterials is revolutionizing drug delivery.
  • Dynamic and responsive materials offer significant potential for treating complex diseases like cancer and infection.
  • Future research will likely focus on further refining these programmable systems for clinical translation.