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Updated: Mar 21, 2026

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Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission
Comfort O Elumogo1, James N Kochenderfer1, A Cahid Civelek1
11 Radiology and Imaging Sciences, National Institutes of Health/Clinical Center, Bethesda, MD 20892, USA ; 2 Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Abstract:
Pigmented villonodular synovitis (PVNS) is a benign joint disease best characterized on magnetic resonance imaging (MRI). The role of fluorine 18 fluorodeoxyglucose ((18)F-FDG) position emission tomography-computed tomography (PET-CT) in the diagnosis or characterization remains unclear. PVNS displays as a focal FDG avid lesion, which can masquerade as a metastatic lesion, on PET-CET. We present a case of PVNS found on surveillance imaging of a lymphoma patient.
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