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Updated: Mar 21, 2026
10:14
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
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Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years
Kamal V Kanodia1, Aruna V Vanikar2, Rashmi D Patel3
1Professor, Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences , Civil Hospital Campus, Asarwa, Ahmedabad, India .
Journal of Clinical and Diagnostic Research : JCDR
|May 19, 2016
Summary
Collapsing glomerulopathy (CG) is a severe podocyte injury pattern. Early detection and mild tubular atrophy/interstitial fibrosis indicate potential for remission in idiopathic CG cases.
Area of Science:
- Nephrology
- Pathology
- Renal Medicine
Background:
- Collapsing glomerulopathy (CG) presents as a distinct pattern of proliferative parenchymal injury.
- CG often shows a poor response to empirical treatment strategies.
Purpose of the Study:
- To investigate the clinicopathological features of idiopathic collapsing glomerulopathy (CG).
Main Methods:
- Retrospective analysis of 3335 native renal biopsies performed between 2008 and 2014.
- Emphasis on clinicopathological correlation and detailed histopathological presentation.
Main Results:
- Idiopathic CG occurred in 0.75% of biopsies (25/3335), with adults comprising 88%.
- Common findings included hypertension (40.9%), oliguria (36.4%), microscopic hematuria (54.5%), and nephrotic-range proteinuria (45.5%) in adults.
- Histopathology revealed podocyte hyperplasia/hypertrophy, microcystic tubular dilation (64%), and varying degrees of tubular atrophy and interstitial fibrosis.
Conclusions:
- Idiopathic CG represents a severe podocyte injury with a generally poor prognosis.
- Remission or recovery is possible in cases with mild (≤t1) tubular atrophy and mild (≤i1) interstitial fibrosis.
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