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Related Concept Videos

Transcription Factors02:16

Transcription Factors

83.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription Factors02:16

Transcription Factors

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Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
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General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Eukaryotic Transcription Activators02:42

Eukaryotic Transcription Activators

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Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
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Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

11.3K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
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Related Experiment Video

Updated: Mar 21, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

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Transcription Factor Drug Targets.

Kostas A Papavassiliou1, Athanasios G Papavassiliou2

  • 1Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece.

Journal of Cellular Biochemistry
|May 19, 2016
PubMed
Summary

Transcription factors are key in cell signaling and disease. New drug discovery shows these proteins can be targeted for therapeutic benefit in various human conditions.

Keywords:
DEREGULATIONHUMAN DISEASEMUTATIONTHERAPEUTIC TARGETTRANSCRIPTION FACTORS

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Drug Discovery

Background:

  • Transcription factors integrate cellular signals and are implicated in numerous diseases, including cancer, diabetes, and inflammatory disorders.
  • Dysregulation of transcription factors plays a critical role in the pathogenesis of many human diseases.
  • These proteins represent significant therapeutic targets due to their central role in disease pathways.

Purpose of the Study:

  • To review recent advances in understanding the role of transcription factors in human diseases.
  • To discuss emerging pharmacological strategies for modulating transcription factor activity.
  • To highlight the therapeutic potential of targeting transcription factors.

Main Methods:

  • Literature review of recent research on transcription factors in disease.
  • Analysis of current drug discovery approaches targeting transcription factors.
  • Synthesis of information on pharmacological strategies for transcription factor modulation.

Main Results:

  • Transcription factors are confirmed as crucial players in the development of diverse human pathologies.
  • Small molecule-based inhibition of transcription factors is a viable and advancing therapeutic strategy.
  • Recent drug discovery efforts demonstrate the feasibility of directly modulating transcription factor function.

Conclusions:

  • Transcription factors are significant targets for therapeutic intervention in a wide range of diseases.
  • Emerging pharmacological strategies offer promising avenues for modulating transcription factor activity.
  • Targeting transcription factors with small molecules represents a realistic and evolving approach in drug development.