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λ-Eye: a high-sensitivity γ imaging probe for axillary sentinel lymph node mapping.

Maria Georgiou¹, George Loudos, Eleftherios Fysikopoulos

¹aDepartment of Nuclear Medicine, Medical School, University of Thessaly, Larissa bR&D, BioEmission Technology Solutions cDepartment of Biomedical Technology, Technological Educational Institute of Athens dInstitute of Radioisotopes and Radiodiagnostic Products, NCSR 'Demokritos', Athens eDepartment of Medical Physics, Medical School, University of Patras, Patra, Greece.

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|May 19, 2016

Summary

The new 'λ-eye' gamma imaging probe offers high sensitivity and good spatial resolution for sentinel lymph node mapping. This compact device is suitable for surgical use and detailed scanning of suspicious regions.

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Area of Science:

Medical Imaging
Nuclear Medicine
Surgical Guidance

Background:

Sentinel lymph node mapping is crucial for cancer staging and treatment planning.
Existing gamma imaging probes may lack the optimal sensitivity or spatial resolution for certain applications.
Previous theoretical models and simulations guided the design of an improved probe.

Purpose of the Study:

To construct and evaluate the performance of the 'λ-eye' gamma imaging probe.
To optimize the probe for enhanced sensitivity in sentinel lymph node mapping.
To experimentally validate simulation results and assess the probe's capabilities in small animal models.

Main Methods:

Construction of the 'λ-eye' gamma imaging probe.
Performance evaluation using phantoms to measure spatial resolution, energy resolution, sensitivity, and uniformity.
Proof-of-concept lymph node imaging in normal mice.

Main Results:

The probe demonstrated an energy resolution of 36±2% and spatial resolution of 2.2 mm at a 2 mm source-collimator distance.
Integral and differential uniformity values were measured within the useful and central fields-of-view.
Clear imaging of mouse lymph nodes was achieved with a 10-second acquisition time.

Conclusions:

The 'λ-eye' probe combines high sensitivity (∼1.5 counts/s/kBq) with good spatial resolution for sentinel lymph node mapping.
Its compact size (40mm×40mm×70mm) facilitates intraoperative use and detailed scanning.
The probe's performance validates its potential for improved surgical guidance and diagnostic imaging.