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Updated: Jun 27, 2026
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Published on: February 1, 2016
Whole-Body Dynamic Positron Emission and Computed Tomography (WBD-PET/CT): Latest Developments, Challenges and
Anastasios Vatalis1, Dimitra Tsivaka1, Varvara Valotassiou2
1Medical Physics Department, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece.
Whole-body dynamic PET/CT imaging offers superior quantitative accuracy by fusing anatomical and functional data. Advancements in hardware and AI pave the way for wider clinical use, overcoming previous scan complexities.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Radiology
Background:
- Whole-body dynamic positron emission tomography/computed tomography (WBD-PET/CT) integrates anatomical and quantitative functional imaging.
- It surpasses static PET/CT limitations by providing multi-parametric physiological process maps.
- Current challenges include complex data acquisition and long scan times.
Purpose of the Study:
- To review recent advancements in WBD-PET/CT technology and data analysis.
- To summarize current challenges hindering widespread clinical adoption.
- To highlight emerging opportunities for WBD-PET/CT in diagnostics and theranostics.
Main Methods:
- Review of latest developments in long-axial-field-of-view (LAFOV) and Time-of-Flight (TOF) PET scanners.
- Integration of low-dose CT scanner technologies.
- Application of direct parametric PET image reconstruction and Artificial Intelligence (AI) in data analysis.
Main Results:
- New hardware and AI-driven analysis enhance quantitative accuracy and precision.
- Overcoming challenges like scan duration and complexity is becoming feasible.
- WBD-PET/CT shows significant potential for improved diagnostic and theranostic capabilities.
Conclusions:
- Latest WBD-PET/CT developments offer unprecedented opportunities for clinical adoption.
- Addressing current challenges will unlock the full potential of this advanced imaging modality.
- WBD-PET/CT is poised to expand its role in clinical practice for diagnosis and therapy.
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