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[CAUSES AND PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER ADENOTONSILLECTOMY IN CHILDREN IN THE GENERAL
Insights
Ondansetron effectively reduced postoperative nausea and vomiting (PONV) in children undergoing adenotonsillectomy. This study compared various prophylactic treatments, finding ondansetron superior to Metoclopramidum and Dexamethasone alone or in combination.
Area of Science:
- Pediatric Anesthesiology
- Pharmacology
- Surgical Outcomes
Background:
- Postoperative nausea and vomiting (PONV) is a common complication in pediatric surgery, particularly after adenotonsillectomy under general anesthesia.
- Effective PONV prophylaxis is crucial for patient recovery and minimizing adverse events, including aspiration and bleeding.
Purpose of the Study:
- To investigate the incidence and causes of PONV following pediatric adenotonsillectomy.
- To compare the efficacy of different PONV prophylaxis regimens in children aged 3-10 years.
Main Methods:
- A study involving 155 children (3-10 years) undergoing adenotonsillectomy.
- Patients were randomized into five groups receiving different PONV prophylaxis: Metoclopramidum, ondansetron, Dexamethasone, Dexamethasone + Metoclopramidum, or no prophylaxis.
- Nausea, vomiting incidence, timing, and character were assessed within the first 24 hours post-operation.
Main Results:
- Overall PONV incidence was 22.6%, with 13.6% experiencing bloody vomiting during emergence or early postoperative period.
- Ondansetron prophylaxis demonstrated the lowest incidence of PONV compared to other treatments.
- The group receiving no PONV prophylaxis exhibited the highest frequency of nausea and vomiting.
Conclusions:
- Ondansetron is the most effective prophylactic agent for PONV in children undergoing adenotonsillectomy.
- Prophylaxis is essential to mitigate PONV, with significant implications for reducing complications like bleeding.
Abstract:
The aim of the research is to determine the reasons of post operative nausea and vomiting and to compare the efficiency of taken PONVprophylaxis after adenotonsillectomy with general anesthesia in children. 155 patients took part in the research work at the age from 3 to 10 years, of ASAI-II physical status, who were operated on in planned order because of adenotonsillectomy. The patients were divided into 5 groups according to the type of holding PONV prophylaxis. The 1-st group consisted of 30 patients who were given antiemetic--Metoclopramidum (0.15 mg/kg); the 2-nd group (30 patients) was given ondansetronum (0.1 mg/kg); the 3-d group also consisted of 30 patients who were given Dexamethasone (0.2 mg/kg, but not more than 8 mg); the 4-th included 30 patients who were given Dexamethasone (0.2 mg/kg, but not more than 8 mg) and Metoclopramidum (0,15 mg/kg) as the antiemetic; the 5-th group the test one, included 35 patients who were not given PONVprophylaxis. During the first day after the operation the amount of nausea and vomiting have been estimated, the time of occurrence and the character of vomiting. According to the results of the research the PONV in postoperative period consisted 22.6% in which in 13.6% vomiting with blood was pointed out during coming out from general anesthesia, and in early post operative period (p < 0.01), which is connected with blood swallowing on the phase of awaking or possible postoperative bleeding. According to given prophylaxis the least number of PONV is revealed in the group which was given ondansetronum, and the high frequency of post operative nausea and vomiting was pointed out in the group which wasn't given prophylaxis of PONV.
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