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Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
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Polymers02:34

Polymers

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Polymers02:34

Polymers

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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

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Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
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Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

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Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
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4D Printed Bifurcated Stents with Kirigami-Inspired Structures
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Stent Polymers: Do They Make a Difference?

Konstantinos D Rizas1, Julinda Mehilli2

  • 1From the Department of Cardiology, Munich University Clinic, Ludwig-Maximilian University, Munich, Germany (K.D.R., J.M.); and Munich Heart Alliance at DZHK, Munich, Germany (J.M.).

Circulation. Cardiovascular Interventions
|May 20, 2016
PubMed
Summary
This summary is machine-generated.

Biodegradable polymers in drug-eluting stents (DES) may reduce inflammation and late stent thrombosis compared to permanent polymers. Further research is needed to confirm long-term safety benefits in newer DES generations.

Keywords:
drug-eluting stentsfollow-up studiespercutaneous coronary interventionpolymersthrombosis

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Medicine
  • Polymer Chemistry

Background:

  • Polymers are crucial for drug-eluting stent (DES) performance, controlling drug release.
  • Permanent polymers can cause chronic inflammation, leading to restenosis and stent thrombosis.
  • Biodegradable polymers offer a potential solution to mitigate these adverse events.

Purpose of the Study:

  • To evaluate the clinical outcomes and safety profile of biodegradable polymer DES.
  • To compare the long-term performance of biodegradable polymer DES with permanent polymer DES.
  • To investigate the persistence of safety benefits with newer biodegradable polymer DES generations.

Main Methods:

  • Clinical testing of various biodegradable polymer DES platforms.
  • Comparison of outcomes between biodegradable and permanent polymer DES groups.
  • Analysis of long-term follow-up data, focusing on restenosis and stent thrombosis rates.

Main Results:

  • Biodegradable polymer DES showed comparable outcomes to permanent polymer DES within the first year.
  • Early biodegradable polymer DES platforms demonstrated promising lower rates of stent thrombosis at longer follow-up.
  • The safety advantage of newer biodegradable polymer DES generations against modern permanent polymer DES requires further investigation.

Conclusions:

  • Biodegradable polymers represent a promising alternative to permanent polymers in DES technology.
  • Early data suggest a potential reduction in late stent thrombosis with biodegradable polymer DES.
  • Long-term comparative studies are essential to validate the sustained safety and efficacy of advanced biodegradable polymer DES.