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Updated: Aug 11, 2026

Application of Electrophysiology Measurement to Study the Activity of Electro-Neutral Transporters
Published on: February 3, 2018
[Cellular electrolyte metabolism and regulation of vascular tonus. Clinical aspects]
1Medizinische Universitäts-Poliklinik, Münster/Westf.
Abstract:
In the pathogenesis of essential hypertension the role of intracellular Na+ concentrations due to the secretion of a yet unidentified natriuretic factor is being discussed. Proceeding from the role of Ca++ in vascular smooth muscle contraction the hypothesis of increased intracellular free Ca++ concentrations in essential hypertension has been proposed. The measurements described here first revealed increased cellular concentrations of free Ca++ in essential hypertensives. Furthermore in essential hypertensives and in the spontaneously hypertensive rat a circulating factor was demonstrated increasing blood pressure and stimulating cellular Ca++ uptake.
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