Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Midazolam for sedation before procedures.

Aaron Conway1, John Rolley, Joanna R Sutherland

  • 1Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

The Cochrane Database of Systematic Reviews
|May 21, 2016
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computer vision for pain detection during procedural sedation.

Scientific reports·2026
Same author

Trajectory prediction in percutaneous coronary intervention recovery.

European journal of cardiovascular nursing·2025
Same author

Communication skills, patient voices and the art of listening.

Anaesthesia and intensive care·2025
Same author

Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool.

JAMA network open·2024
Same author

Designing the User Interface of a Nitroglycerin Dose Titration Decision Support System: User-Centered Design Study.

Applied clinical informatics·2024
Same author

Integrated pulmonary index during procedural sedation and analgesia: A cluster-randomized trial.

Journal of advanced nursing·2024
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

This review found limited high-quality evidence on midazolam

Area of Science:

  • Pharmacology
  • Anesthesiology
  • Evidence-based medicine

Background:

  • Midazolam, an imidazole benzodiazepine, is widely used for procedural sedation due to its rapid onset and favorable safety profile.
  • It can be administered via oral, intravenous, intranasal, and intramuscular routes.
  • Understanding its effectiveness compared to placebo and other sedatives is crucial for optimizing procedural care.

Purpose of the Study:

  • To systematically review and synthesize evidence on the effectiveness of midazolam for sedation prior to diagnostic or therapeutic medical procedures.
  • To compare midazolam's efficacy against placebo and other sedative or analgesic agents across various administration routes.

Main Methods:

  • A comprehensive search of major databases (CENTRAL, MEDLINE, EMBASE) was conducted up to January 2016.

Related Experiment Videos

  • Included were randomized controlled trials comparing midazolam (any route, dose, or timing) with placebo or other medications.
  • Data extraction and risk of bias assessment were performed independently by two authors.

    • Main Results:

    • Thirty trials involving 2319 participants were included, covering procedures like gastrointestinal endoscopy and bronchoscopy.
    • Intravenous midazolam showed no significant difference in anxiety or pain compared to diazepam but improved amnesia.
    • Oral midazolam demonstrated potential for reducing pain and anxiety versus placebo, but evidence was inconsistent and moderate-quality evidence suggested it was less effective than chloral hydrate for procedure completion in children.

    Conclusions:

    • High-quality evidence is lacking to definitively establish midazolam's superiority over placebo or other agents as a sole sedative.
    • Low-quality evidence suggests intravenous midazolam may reduce anxiety compared to placebo.
    • Oral midazolam's effectiveness for anxiety reduction is inconsistent, and it may be less effective than chloral hydrate for procedure completion in pediatric patients.