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Updated: Mar 21, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Is the naturalistic course of depression in older people related to received support over time? Results from a
Wim Houtjes1,2,3, Dorly Deeg2, Peter M van de Ven2
1GGZ-VS, Academy for Masters in Advanced Nursing Practice, Utrecht, The Netherlands.
Objectives:
To test the interrelation of the naturalistic course of depression in older people with long-term support received.
Design:
Longitudinal cohort study.
Methods:
A sample of 277 adults age 55-85 years participating in the Longitudinal Aging Study Amsterdam, with clinically relevant depressive symptoms at baseline (scores ≥16 on the Center for Epidemiological Studies Depression Scale) were followed up over a period of 13 years. General estimating equations were used to examine the relation between depression course and emotional/instrumental support received over time. In addition, partner status, gender, and age were tested as modifiers.
Results:
A 2-way interaction between depression courses types and time showed significant differences in instrumental support received over time in older people with a late-life depression. Three-way interactions showed that associations between depression course and support variables were modified by gender and partner status.
Conclusion:
Both men and singles, with a chronic course of depression may be at risk to lose emotional and instrumental support over time. Professional attention is needed to prevent a chronic course of late-life depression, and to preserve personal social networks. Copyright © 2016 John Wiley & Sons, Ltd.
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