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Fluoride: a risk factor for inflammatory bowel disease?
Benoit Follin-Arbelet1, Bjørn Moum2
1a Department of Gene Technology , Akershus University Hospital , Lørenskog , Norway ;
Scandinavian Journal of Gastroenterology
|May 21, 2016
Summary
Prolonged fluoride exposure may be indirectly linked to inflammatory bowel disease (IBD) incidence. Further research is needed to explore fluoride
Area of Science:
- Gastroenterology
- Toxicology
- Microbiology
Background:
- The link between oral hygiene and inflammatory bowel disease (IBD) is known.
- Research on prolonged fluoride exposure as an IBD risk factor is limited.
Purpose of the Study:
- To investigate the potential association between fluoride exposure and IBD.
- To explore fluoride's role in IBD pathogenesis.
Main Methods:
- Review of fluoride toxicology and epidemiology data.
- Analysis of potential mechanisms involving efflux genes and gut microbiota.
Main Results:
- Fluoride exposure appears indirectly associated with increased IBD incidence.
- Fluoride toxicology studies report chronic gastrointestinal symptoms and inflammation.
- Efflux genes conferring fluoride resistance may influence IBD-associated gut microbiota.
Conclusions:
- Multidisciplinary evidence suggests fluoride warrants investigation as a potential IBD risk factor.
- Further research is recommended to validate the hypothesis of fluoride's role in IBD development.
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