Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
What is the Immune System?01:38

What is the Immune System?

144.1K
Overview
144.1K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

4.0K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
4.0K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.9K
Overview
85.9K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.8K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative performance of lupus disease-activity indices during pregnancy to predict adverse obstetric outcomes: A colombian SLE cohort.

Lupus·2026
Same author

Performance of predictive scores for in-hospital mortality in surgical infective endocarditis: a retrospective cohort study.

Frontiers in cardiovascular medicine·2026
Same author

Severity of SARS-CoV-2 infection increases the risk of generalized anxiety disorder, major depressive disorder, and post-traumatic stress disorder in COVID-19 survivors: a prospective longitudinal cohort study.

Brain, behavior, & immunity - health·2026
Same author

Immunosenescence and human healthspan. Lessons from centenarians.

Current opinion in immunology·2026
Same author

Comparison of lymphocyte populations, cytokine, and autoantibody profile in patients with rheumatoid arthritis: a study of cases with COVID-19 and controls without COVID-19.

Journal of infection in developing countries·2026
Same author

Mechanical ventilation as an independent risk factor for mortality in COVID-19-related ARDS: A secondary analysis using propensity score weighting.

PloS one·2026

Related Experiment Video

Updated: Mar 20, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.6K

The Autoimmune Ecology.

Juan-Manuel Anaya1, Carolina Ramirez-Santana1, Maria A Alzate1

  • 1Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario , Bogotá , Colombia.

Frontiers in Immunology
|May 21, 2016
PubMed
Summary

Environmental factors significantly influence autoimmune diseases (ADs), impacting immune system function. Understanding autoimmune ecology, or the exposome, is key to personalized medicine and managing AD risk.

Keywords:
autoimmune diseaseecologyenvironmentpersonalized medicinepolyautoimmunity

More Related Videos

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.4K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K

Related Experiment Videos

Last Updated: Mar 20, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.6K
Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.4K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K

Area of Science:

  • Immunology
  • Environmental Health
  • Genetics

Background:

  • Autoimmune diseases (ADs) are a diverse group of disorders with shared immunopathogenic mechanisms.
  • Familial clustering suggests a genetic component, but environmental influences are increasingly recognized.
  • The concept of 'autoimmune ecology' highlights the interaction between environmental exposures and genetic/epigenetic factors.

Purpose of the Study:

  • To provide an overview of autoimmune ecology and its role in the development of ADs.
  • To emphasize the significant impact of environmental factors on immune system modulation.
  • To explore how understanding autoimmune ecology can advance personalized medicine.

Main Methods:

  • Review of existing literature on autoimmune diseases and environmental exposures.
  • Focus on specific environmental factors including microbiota, smoking, alcohol, coffee, SES, hormones, vitamin D, solvents, and vaccines.
  • Conceptual framework linking exposome, genetics, epigenetics, and autoimmunity.

Main Results:

  • Environment plays a critical role, often more than genetics, in shaping the immune system and AD risk.
  • Specific environmental agents like microbiota, smoking, and vitamin D levels are implicated in AD pathogenesis.
  • The interplay between internal/external exposures (exposome) and host factors determines autoimmunity.

Conclusions:

  • Autoimmune ecology is a crucial determinant of AD development and outcomes.
  • Integrating the exposome into disease etiology is essential for improving personalized medicine approaches.
  • Further research into autoimmune ecology can lead to better prevention and treatment strategies for ADs.