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Protein Kinase D1 Signaling in Angiogenic Gene Expression and VEGF-Mediated Angiogenesis

Bin Ren1

  • 1Department of Medicine, Medical College of WisconsinMilwaukee, WI, USA; Blood Research Institute, Blood Center of WisconsinMilwaukee, WI, USA.

Frontiers in Cell and Developmental Biology
|May 21, 2016
PubMed

Insights

Protein kinase D 1 (PKD-1) regulates gene expression and angiogenesis, crucial for cardiovascular health and cancer. Understanding PKD-1

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Cardiovascular Biology

Background:

  • Protein kinase D 1 (PKD-1) is a key signaling kinase involved in cell migration, proliferation, and differentiation.
  • PKD-1 plays a critical role in regulating gene expression and angiogenesis, processes vital for cardiovascular development and tumor progression.

Purpose of the Study:

  • To elucidate the molecular mechanisms of PKD-1 in regulating the transcriptional expression of angiogenic genes.
  • To focus on the PKD-1-FoxO1 signaling axis in the transcriptional regulation of CD36 and its role in arterial differentiation and morphogenesis.
  • To discuss the concept of dynamic balance in angiogenic signaling and PKD-1's regulation of VEGF signaling-mediated angiogenesis.

Main Methods:

  • Review and synthesis of existing literature on PKD-1 signaling pathways.
  • Analysis of molecular mechanisms underlying transcriptional regulation of angiogenic genes.
  • Exploration of the role of the PKD-1-FoxO1-CD36 axis in angiogenesis and arterial development.

Main Results:

  • PKD-1 signaling directly influences the transcriptional regulation of angiogenic genes, including CD36 via the FoxO1 axis.
  • The PKD-1-FoxO1 signaling pathway is implicated in arterial differentiation and morphogenesis.
  • PKD-1 signaling is a critical modulator of VEGF signaling-mediated angiogenesis, contributing to the balance of pro- and anti-angiogenic factors.

Conclusions:

  • Understanding PKD-1's role in angiogenesis offers translational potential for treating obesity, cardiovascular diseases, and cancer.
  • The PKD-1-FoxO1-CD36 axis represents a novel target for modulating angiogenesis.
  • PKD-1 signaling is central to the dynamic regulation of angiogenesis, impacting vascular development and disease progression.
Keywords:
CD36VEGFangiogenesisarteriogenesisendothelial cellsgene expressionprotein kinase Dtranscription

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