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Related Experiment Videos

Plasma eicosanoids, platelet function and cold sensitivity.

D Wilkinson1, P Vowden, L Gilks

  • 1Department of Vascular Surgery, St. James's University Hospital, Leeds, UK.

The British Journal of Surgery
|April 1, 1989
PubMed
Summary

Abnormal eicosanoid metabolism is linked to vasospastic diseases. Patients with vibration white finger (VWF) and Raynaud

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Area of Science:

  • Biochemistry
  • Vascular Biology
  • Immunology

Background:

  • Abnormal eicosanoid metabolism is implicated in vasospastic diseases.
  • Eicosanoids, such as prostaglandins, play key roles in vascular function and inflammation.

Purpose of the Study:

  • To investigate eicosanoid metabolism and platelet aggregation in patients with Raynaud's phenomenon and vibration white finger (VWF).
  • To compare these parameters between primary Raynaud's, secondary Raynaud's (to scleroderma), and VWF disease.

Main Methods:

  • Radioimmunoassay was used to measure stable eicosanoid metabolites.
  • Platelet aggregation was measured in response to adenosine diphosphate (ADP), collagen, and adrenaline.

Main Results:

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  • VWF patients showed elevated thromboxane B2 with normal 6-keto-prostaglandin F1 alpha and reduced platelet sensitivity to ADP and collagen.
  • Primary Raynaud's patients had elevated thromboxane B2 and normal 6-keto-prostaglandin F1 alpha, with increased platelet sensitivity.
  • Secondary Raynaud's patients exhibited markedly elevated thromboxane B2 and 6-keto-prostaglandin F1 alpha, with significantly increased platelet sensitivity.

    • Conclusions:

    • Distinct eicosanoid and platelet profiles are observed in VWF and Raynaud's phenomenon.
    • Secondary Raynaud's shows more pronounced alterations in eicosanoid metabolism and platelet activity.
    • The causal relationship between these observed phenomena and vasospasm requires further investigation.