Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma eicosanoids, platelet function and cold sensitivity.

D Wilkinson1, P Vowden, L Gilks

  • 1Department of Vascular Surgery, St. James's University Hospital, Leeds, UK.

The British Journal of Surgery
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of first birth by cesarean delivery on subsequent reproductive outcomes-a population cohort study.

American journal of obstetrics and gynecology·2026
Same author

The Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites (TRACERS) Science Operations Center.

Space science reviews·2025
Same author

The Magnetic Search Coil (MSC) on the TRACERS Mission.

Space science reviews·2025
Same author

The metabolic effects of intermittent versus continuous feeding in critically ill patients.

Scientific reports·2023
Same author

Defining complexity in anaesthesia: description and validation of the Oxford Anaesthetic Complexity (OxAnCo) score.

Anaesthesia·2022
Same author

Infectious mononucleosis - should we routinely assess liver function in acute presentation and follow up?

The Journal of laryngology and otology·2022
Same journal

Trimester-Specific Safety of Laparoscopic versus Open Abdominal Surgery During Pregnancy: A Systematic Review and Meta-analysis.

The British journal of surgery·2026
Same journal

The Gut Microbiome in Surgical Oncology: Mechanisms, Perioperative Outcomes, and Therapeutic Opportunities.

The British journal of surgery·2026
Same journal

Patient-led, home-based follow-up for colorectal cancer: the DISTANCE multicentre stepped-wedge cluster-randomised trial.

The British journal of surgery·2026
Same journal

Correction to: Reduced secretory efficiency in parathyroid carcinoma: diagnostic value of the PTH-to-tumour-volume ratio.

The British journal of surgery·2026
Same journal

Global disparities in hepatocellular carcinoma outcomes: multicentre study.

The British journal of surgery·2026
Same journal

Surgical Outcomes from Nationwide Implementation of the International Best-Practice for Locally Advanced Pancreatic Cancer (PREOPANC-4) study.

The British journal of surgery·2026
See all related articles

Abnormal eicosanoid metabolism is linked to vasospastic diseases. Patients with vibration white finger (VWF) and Raynaud

Area of Science:

  • Biochemistry
  • Vascular Biology
  • Immunology

Background:

  • Abnormal eicosanoid metabolism is implicated in vasospastic diseases.
  • Eicosanoids, such as prostaglandins, play key roles in vascular function and inflammation.

Purpose of the Study:

  • To investigate eicosanoid metabolism and platelet aggregation in patients with Raynaud's phenomenon and vibration white finger (VWF).
  • To compare these parameters between primary Raynaud's, secondary Raynaud's (to scleroderma), and VWF disease.

Main Methods:

  • Radioimmunoassay was used to measure stable eicosanoid metabolites.
  • Platelet aggregation was measured in response to adenosine diphosphate (ADP), collagen, and adrenaline.

Main Results:

Related Experiment Videos

  • VWF patients showed elevated thromboxane B2 with normal 6-keto-prostaglandin F1 alpha and reduced platelet sensitivity to ADP and collagen.
  • Primary Raynaud's patients had elevated thromboxane B2 and normal 6-keto-prostaglandin F1 alpha, with increased platelet sensitivity.
  • Secondary Raynaud's patients exhibited markedly elevated thromboxane B2 and 6-keto-prostaglandin F1 alpha, with significantly increased platelet sensitivity.

    • Conclusions:

    • Distinct eicosanoid and platelet profiles are observed in VWF and Raynaud's phenomenon.
    • Secondary Raynaud's shows more pronounced alterations in eicosanoid metabolism and platelet activity.
    • The causal relationship between these observed phenomena and vasospasm requires further investigation.