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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Classification01:23

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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A System to Create Stable Nanoparticle Aerosols from Nanopowders
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Electrosprayed nanoparticle delivery system for controlled release.

Megdi Eltayeb1, Eleanor Stride2, Mohan Edirisinghe3

  • 1Department of Biomedical Engineering, Sudan University of Science and Technology, PO Box 407, Khartoum, Sudan.

Materials Science & Engineering. C, Materials for Biological Applications
|May 22, 2016
PubMed
Summary
This summary is machine-generated.

Electrohydrodynamic techniques create tunable core-shell lipid nanoparticles for efficient active ingredient delivery. Release rates depend on nanoparticle size and lipid composition, offering controlled drug release potential.

Keywords:
Controlled releaseElectrohydrodynamic processingLipid nanoparticles

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Lipid nanoparticles (LNPs) are crucial for drug delivery.
  • Controlling LNP size, loading, and release is essential for efficacy.
  • Existing methods may have limitations in tunability and efficiency.

Purpose of the Study:

  • To develop core-shell LNPs using electrohydrodynamics.
  • To investigate the influence of processing conditions on LNP characteristics.
  • To analyze the controlled release of active ingredients from LNPs.

Main Methods:

  • Utilized an electrohydrodynamic technique for LNP preparation.
  • Employed stearic acid as the shell and ethylvanillin as the model active ingredient.
  • Characterized LNP size, polydispersity, encapsulation efficiency, and internal structure (TEM, FTIR).

Main Results:

  • Successfully prepared core-shell LNPs with tunable sizes (60-70nm) and high encapsulation efficiency (~70%).
  • Demonstrated controlled release of ethylvanillin, dependent on LNP size and lipid:ethylvanillin ratio.
  • Confirmed core-shell structure and integrity of the active ingredient post-encapsulation.

Conclusions:

  • Electrohydrodynamics is a viable method for producing high-quality core-shell LNPs.
  • Tunable LNP properties enable tailored drug delivery systems.
  • The developed model accurately describes ethylvanillin release kinetics.