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Updated: Mar 20, 2026
An In Vitro Model to Study the Effect of 5-Aminolevulinic Acid-mediated Photodynamic Therapy on Staphylococcus aureus Biofilm
Published on: April 16, 2018
Evaluation of Antimicrobial Photodynamic Therapy against Streptococcus mutans Biofilm in situ
V H Panhóca1, Fle Florez2, N Batista de Faria3
1University of São Paulo-USP, Physics Institute of São Carlos-IFSC, Optical Group, Biophotonics Laboratory; Federal University of São Carlos-UFSCar, Biotechnology Postgraduate Program, Sao Carlos, São Paulo, Brazil.
Aim:
This study investigated the effect of antimicrobial photo-dynamic therapy (aPDT) over Streptococcus mutans biofilm.
Materials And Methods:
Eighteen (n = 18) patients were selected and one palatine device with dental blocks was used. The biofilm was treated by curcumin and Photogem® with a LED and the effect was analyzed by CFU/ml.
Results:
Although, statistical analysis showed significant reductions for aPDT mainly with Photogem® (p = 0.02), these were low.
Conclusion:
The results suggest a low antimicrobial effect of aPDT over S. mutans biofilm. Some parameters used need to be improved.
Clinical Significance:
This technique can be a promising in Dentistry.
