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Related Concept Videos

Epistasis01:39

Epistasis

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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Pregnancy and Nursing Management for Embryo-Transferred and Genetically Modified Rabbits
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Embryologic changes in rabbit lines selected for litter size variability.

M L García1, A Blasco2, M J Argente1

  • 1Departamento de Tecnología Agroalimentaria, Universidad Miguel Hernández de Elche, Orihuela, Spain.

Theriogenology
|May 22, 2016
PubMed
Summary
This summary is machine-generated.

Selection for litter size variability impacts early embryo development. Embryos from high-variability lines show reduced normal embryo rates and slower development, affecting reproductive success.

Keywords:
Embryonic coatEmbryonic developmentLitter size variabilityRabbitSelection

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Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Animal Genetics

Background:

  • Divergent selection experiments are crucial for understanding trait evolution.
  • Litter size variability is a complex trait influenced by multiple genetic and environmental factors.
  • Early embryonic development is a critical period for reproductive success.

Purpose of the Study:

  • To investigate the correlated responses in early embryonic development following divergent selection for litter size variability.
  • To assess the impact of selection on embryo survival, developmental stage, and physical characteristics.

Main Methods:

  • A divergent selection experiment was conducted over four generations.
  • Embryos from high-line and low-line females were analyzed at 24, 48, and 72 hours postcoitum (hpc).
  • Key traits measured included percentage of normal embryos, embryo diameter, zona pellucida thickness, and mucin coat thickness.

Main Results:

  • High-line embryos exhibited a lower percentage of normal embryos at 24 hpc.
  • Embryos from the high line showed delayed development at 48 and 72 hpc, with fewer reaching the blastocyst stage.
  • No significant differences were observed in embryo diameter or mucin coat thickness between the lines.

Conclusions:

  • Selection for litter size variability has significant consequences on early embryonic survival and developmental progression.
  • Embryos from lines selected for higher variability display compromised development and reduced normality.
  • These findings highlight the intricate relationship between selection for reproductive traits and embryonic viability.