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Updated: Mar 20, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
Drug-Resistant Tuberculosis: Challenges and Progress
Sebastian G Kurz1, Jennifer J Furin2, Charles M Bark3
1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Tufts University School of Medicine, 800 Washington Street, #257, Boston, MA 02111, USA.
Abstract:
Antimicrobial resistance is a natural evolutionary process, which in the case of Mycobacterium tuberculosis is based on spontaneous chromosomal mutations, meaning that well-designed combination drug regimens provided under supervised therapy will prevent the emergence of drug-resistant strains. Unfortunately, limited resources, poverty, and neglect have led to the emergence of drug-resistant tuberculosis throughout the world. The international community has responded with financial and scientific support, leading to new rapid diagnostics, new drugs and regimens in advanced clinical development, and an increasingly sophisticated understanding of resistance mechanisms and their application to all aspects of TB control and treatment.
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