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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tumor Immunotherapy

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Updated: Mar 20, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

Tumor-targeting peptides from combinatorial libraries.

Ruiwu Liu¹, Xiaocen Li¹, Wenwu Xiao¹

¹Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA; University of California Davis Comprehensive Cancer Center, Sacramento, CA 95817, USA.

Advanced Drug Delivery Reviews

|May 24, 2016

Summary

This summary is machine-generated.

Discovering tumor-targeting peptides is crucial for early cancer detection and effective treatments. Combinatorial library technologies like phage display and one-bead one-compound (OBOC) are key methods for identifying these vital peptide ligands.

Keywords:

Biological library Cell surface receptor High throughput screening One-bead one-compound peptide library Phage-display peptide library Tumor-targeting peptide

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Area of Science:

Oncology
Molecular Biology
Drug Discovery

Background:

Cancer remains a leading global cause of mortality, with significant challenges in early detection and treatment side effects.
Targeted therapies and molecular imaging necessitate high-affinity, tumor-specific agents for delivering therapeutics and imaging probes.
Combinatorial libraries offer powerful strategies for identifying peptides that target tumors.

Purpose of the Study:

To provide an overview of combinatorial library technologies used for discovering tumor-targeting peptides.
To discuss examples of tumor-targeting peptides identified using these methods.
To summarize published peptide ligands, their applications, and corresponding binding receptors.

Main Methods:

Phage-display peptide libraries
One-bead one-compound (OBOC) peptide libraries
Review of existing literature on combinatorial library technologies for peptide discovery

Main Results:

Various combinatorial library technologies have been successfully employed to discover tumor-targeting peptides.
Specific examples of identified peptide ligands and their targeted receptors are presented.
The review categorizes and summarizes peptide ligands based on discovery method and binding targets.

Conclusions:

Combinatorial libraries are essential tools for identifying effective tumor-targeting peptides.
These peptides hold significant potential for advancing cancer diagnostics and therapeutics.
Further research into peptide ligands and their applications can improve cancer patient outcomes.