Related Experiment Video
Updated: Mar 20, 2026
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
Tumor-targeting peptides from combinatorial libraries
Ruiwu Liu1, Xiaocen Li1, Wenwu Xiao1
1Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA; University of California Davis Comprehensive Cancer Center, Sacramento, CA 95817, USA.
Abstract:
Cancer is one of the major and leading causes of death worldwide. Two of the greatest challenges in fighting cancer are early detection and effective treatments with no or minimum side effects. Widespread use of targeted therapies and molecular imaging in clinics requires high affinity, tumor-specific agents as effective targeting vehicles to deliver therapeutics and imaging probes to the primary or metastatic tumor sites. Combinatorial libraries such as phage-display and one-bead one-compound (OBOC) peptide libraries are powerful approaches in discovering tumor-targeting peptides. This review gives an overview of different combinatorial library technologies that have been used for the discovery of tumor-targeting peptides. Examples of tumor-targeting peptides identified from each combinatorial library method will be discussed. Published tumor-targeting peptide ligands and their applications will also be summarized by the combinatorial library methods and their corresponding binding receptors.
Insights
Discovering tumor-targeting peptides is crucial for early cancer detection and effective treatments. Combinatorial library technologies like phage display and one-bead one-compound (OBOC) are key methods for identifying these vital peptide ligands.
Area of Science:
- Oncology
- Molecular Biology
- Drug Discovery
Background:
- Cancer remains a leading global cause of mortality, with significant challenges in early detection and treatment side effects.
- Targeted therapies and molecular imaging necessitate high-affinity, tumor-specific agents for delivering therapeutics and imaging probes.
- Combinatorial libraries offer powerful strategies for identifying peptides that target tumors.
Purpose of the Study:
- To provide an overview of combinatorial library technologies used for discovering tumor-targeting peptides.
- To discuss examples of tumor-targeting peptides identified using these methods.
- To summarize published peptide ligands, their applications, and corresponding binding receptors.
Main Methods:
- Phage-display peptide libraries
- One-bead one-compound (OBOC) peptide libraries
- Review of existing literature on combinatorial library technologies for peptide discovery
Main Results:
- Various combinatorial library technologies have been successfully employed to discover tumor-targeting peptides.
- Specific examples of identified peptide ligands and their targeted receptors are presented.
- The review categorizes and summarizes peptide ligands based on discovery method and binding targets.
Conclusions:
- Combinatorial libraries are essential tools for identifying effective tumor-targeting peptides.
- These peptides hold significant potential for advancing cancer diagnostics and therapeutics.
- Further research into peptide ligands and their applications can improve cancer patient outcomes.
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:57Targeted Cancer Therapies
01:27Tumor Immunotherapy