The First Report of Urothelial (Clear Cell Variant) Bladder Cancer in a Child
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Updated: Mar 20, 2026
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
Shaul Yosef Minkowitz1, Reubina Wadee2, Ahmed Adam3
1Department of Urology, Helen Joseph Hospital, Johannesburg, South Africa; Department of Paediatric Urology, Rahima Moosa Mother & Child (Coronation) Hospital, Johannesburg, South Africa; Division of Urology, University of the Witwatersrand, Johannesburg, South Africa; Division of Anatomical Pathology, University of the Witwatersrand and the National Health Laboratory Services (NHLS), Johannesburg, South Africa.
Abstract:
Urothelial bladder tumours in childhood are extremely rare, with most cases being low grade, superficial disease of the papillary subtype with favourable outcomes. Urothelial (clear cell variant) carcinoma of bladder (UCCVCB) is an exceptional histological finding in both the adult and paediatric population. Herein we describe the first case of UCCVCB diagnosed in childhood. With this case being only the fourth report of confirmed muscle invasion in childhood, we discuss the entity of UCCVCB, and furthermore review all previously reported confirmed cases of childhood muscle invasive urothelial bladder cancer, in general.
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