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Updated: Jul 28, 2026
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
Published on: June 22, 2012
Endothelial microparticles induce vascular endothelial cell injury in children with Kawasaki disease
1Department of Cardiology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R. China. tal0979@163.com.
Objective:
To explore the role of microparticles produced by endothelial cells in the injury of vascular endothelial cells.
Materials And Methods:
We stimulated human umbilical vein endothelial cells (HUVEC) with TNF-α in vitro, analyzed the change of cellular morphology, and measured EMP level in the supernatant with a flow cytometer. Then, we evaluated the corresponding clinical indicators and the role of EMP in endothelial injury.
Results:
The endothelial cellular morphology underwent significant changes, and a large number of microparticles were secreted. In turn, these microparticles blocked cell cycle and induced apoptosis.
Conclusions:
The microparticles produced by endothelial cells play an important role in the injury of vascular endothelial cells.
