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Canine and Human Atopic Dermatitis: Two Faces of the Same Host-Microbe Interaction
Domenico Santoro1, Aline Rodrigues Hoffmann2
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
The Journal of Investigative Dermatology
|May 24, 2016
Summary
Atopic dermatitis in dogs is linked to host-microbe interactions. This study found correlations between canine skin microbiome diversity, clinical signs, and skin barrier function during antimicrobial therapy.
Area of Science:
- Veterinary Dermatology
- Microbiology
- Immunology
Background:
- Host-microbe interactions are crucial in atopic dermatitis pathogenesis.
- Dogs serve as a valuable model for studying atopic dermatitis, including its pathogenesis and microbiome alterations.
Purpose of the Study:
- To investigate the correlation between microbiome diversity, clinical manifestations, and skin barrier integrity in atopic dogs.
- To assess changes in the skin microbiome during and after antimicrobial therapy in canine atopic dermatitis.
Main Methods:
- Longitudinal study design tracking atopic dogs.
- Assessment of clinical signs of atopic dermatitis.
- Evaluation of skin barrier function.
- Analysis of skin microbiome diversity using molecular techniques.
Main Results:
- Significant correlations were observed between skin microbiome diversity and clinical signs of atopic dermatitis.
- Skin barrier function was significantly correlated with microbiome diversity.
- Changes in microbiome diversity were noted before, during, and after antimicrobial treatment.
Conclusions:
- Canine atopic dermatitis pathogenesis is significantly influenced by host-microbe interactions.
- Skin microbiome diversity is a key factor affecting clinical signs and skin barrier function in atopic dogs.
- Antimicrobial therapy impacts the skin microbiome, with implications for disease management.
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