Related Experiment Videos
[Contact allergy to a new preservative]
Dermatosen in Beruf Und Umwelt. Occupation and Environment
|March 1, 1989
Summary
A woman developed facial contact eczema from a wrinkle cream. Patch testing identified Euxyl K 400, specifically 1,2-dibromo-2,4-dicyanobutane, as the allergen, suggesting its inclusion in standard patch tests.
Area of Science:
- Dermatology
- Toxicology
- Cosmetic Science
Context:
- Contact eczema is a common skin reaction.
- Non-prescription cosmetic products can cause adverse reactions.
- Euxyl K 400 is a preservative used in cosmetics.
Purpose:
- To identify the cause of contact eczema in a patient.
- To evaluate the allergenic potential of a cosmetic product and its components.
- To assess the role of Euxyl K 400 and its constituents in allergic contact dermatitis.
Summary:
- A 43-year-old woman presented with facial and neck contact eczema after using a non-prescription wrinkle cream.
- Patch testing confirmed the cosmetic product and its preservative, Euxyl K 400, as the cause.
- Further testing revealed 1,2-dibromo-2,4-dicyanobutane within Euxyl K 400 as the specific allergen, eliciting a strong reaction at a low concentration (0.004%).
Impact:
- Highlights the potential for non-prescription cosmetics to cause allergic contact dermatitis.
- Identifies 1,2-dibromo-2,4-dicyanobutane as a significant contact allergen.
- Recommends considering Euxyl K 400 for inclusion in standard patch test batteries for diagnosing cosmetic-related eczema.