Related Experiment Video
Updated: Mar 20, 2026

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
Published on: March 3, 2023
Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium
George R Pettit1, Qinghua Ye1, Delbert L Herald1
1Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
Abstract:
The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1-4) were isolated, accompanied by four previously known triterpenes (5-8). Against a panel of human tumor cell lines, lugardstatins 1 (1) and 2 (2) had good cancer cell growth inhibitory activity. All of the triterpene structures (1-8) were established by 1D and 2D NMR spectrometric and HR mass spectrometric analysis.
Related Concept Videos
Drugs that Stabilize Microtubules
Drugs that Destabilize Microtubules

