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Polymorphisms Associated with Increased Cardiovascular Risk in the General Population do not Predict Acute Events in

Roberta Rolla, Andreana De Mauri, Matteo Vidali

    Clinical Laboratory
    |May 25, 2016
    PubMed

    Insights

    Genetic factors common in the general population do not predict cardiovascular events in hemodialysis patients. This study found no association between these polymorphisms and cardiac or vascular events in this high-risk group.

    Area of Science:

    • Nephrology
    • Cardiology
    • Genetics

    Background:

    • Cardiovascular diseases (CVD) are a primary cause of death in hemodialysis patients (HP).
    • Understanding genetic predispositions to CVD in HP is crucial for developing new prevention strategies.
    • This study investigates known genetic risk factors for CVD in the general population within the HP cohort.

    Purpose of the Study:

    • To analyze specific genetic polymorphisms in hemodialysis patients.
    • To determine if these polymorphisms, associated with CVD risk in the general population, are also prevalent in HP.
    • To assess the predictive value of these genetic factors for cardiovascular events in HP.

    Main Methods:

    • Genotyping of 102 hemodialysis patients for 15 cardiovascular risk-associated polymorphisms.
    • Comparison of polymorphism prevalence in HP versus the general Caucasian population.
    • Correlation analysis between identified polymorphisms and recorded cardiovascular events over an 18-month follow-up.

    Main Results:

    • Prevalence of FV H1299R, PAI-1 (4G/5G), and Factor XIII V34L polymorphisms was significantly higher in HP compared to the general population.
    • No significant differences were found for other analyzed polymorphisms.
    • None of the investigated genetic polymorphisms were associated with cardiovascular events in HP during the follow-up period.

    Conclusions:

    • Traditional genetic risk factors for cardiovascular disease do not appear to predict acute cardiac, peripheral vascular, or cerebral vascular events in hemodialysis patients.
    • These findings suggest that other factors may be more influential in determining cardiovascular outcomes in this patient population.
    • Further research is needed to identify novel predictive markers and prevention strategies for CVD in HP.
    Abstract

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