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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Related Experiment Video

Updated: Mar 20, 2026

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Published on: May 27, 2016

Microfluidic Exosome Analysis toward Liquid Biopsy for Cancer.

Mei He¹, Yong Zeng²

¹Department of Biological and Agricultural Engineering, College of Engineering, Kansas State University, Manhattan, KS, USA.

Journal of Laboratory Automation

|May 25, 2016

Summary

This summary is machine-generated.

Liquid biopsy using circulating exosomes offers noninvasive cancer monitoring. Microfluidic technologies are advancing exosome isolation and characterization for precision medicine applications.

Keywords:

cancer exosomes liquid biopsy microfluidic lab-on-a-chip technology precision medicine

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Last Updated: Mar 20, 2026

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Published on: May 27, 2016

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

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Published on: May 24, 2019

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Area of Science:

Biomedical Engineering
Molecular Oncology
Nanotechnology

Background:

Liquid biopsy enables noninvasive cancer monitoring by analyzing biofluid samples.
Circulating exosomes are valuable tumor surrogates, carrying essential biomarkers like proteins, RNAs, and DNA.
Exosome purification and characterization present significant technical challenges.

Purpose of the Study:

To review state-of-the-art microfluidic technologies for exosome isolation and molecular characterization.
To highlight the applications of these microfluidic technologies in liquid biopsy for cancer analysis.
To discuss current challenges and future directions in microfluidic exosome analysis.

Main Methods:

Review of microfluidic lab-on-a-chip technologies for exosome analysis.
Focus on integration, automation, enhanced sensing, and expedited analysis.
Emphasis on applications in cancer liquid biopsy.

Main Results:

Microfluidic technologies effectively address challenges in exosome purification and characterization.
These technologies offer advantages in integration, automation, and sensing performance.
Significant advancements in microfluidic applications for cancer liquid biopsy are presented.

Conclusions:

Microfluidic technologies are crucial for advancing exosome-based liquid biopsy in cancer.
Continued development is needed to overcome current challenges and optimize exosome analysis.
Future directions include further integration and automation for enhanced clinical utility.