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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
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Curcumin in Treating Breast Cancer: A Review.

Yiwei Wang1,2, Jiayi Yu2, Ran Cui2

  • 1School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai, China.

Journal of Laboratory Automation
|June 22, 2016
PubMed
Summary
This summary is machine-generated.

Curcumin, derived from turmeric, shows anticancer and chemoprevention effects against breast cancer by influencing key molecular pathways. This review explores its molecular targets and mechanisms in breast cancer cells.

Keywords:
breast cancercurcuminnatural compoundsignaling pathways

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Breast cancer is a leading cause of cancer mortality in women.
  • Curcumin, a turmeric derivative, exhibits potential anticancer properties.
  • Understanding curcumin's molecular mechanisms in breast cancer is crucial.

Purpose of the Study:

  • To review recent research on curcumin's molecular targets in breast cancer.
  • To elucidate the anticancer mechanisms of curcumin.
  • To explore curcumin's effects on key signaling pathways.

Main Methods:

  • Literature review of recent research efforts.
  • Analysis of studies investigating curcumin's effects on molecular signaling networks.
  • Examination of evidence on apoptosis and cell cycle regulation.

Main Results:

  • Curcumin impacts breast cancer through complex molecular signaling.
  • It affects proliferation, estrogen receptor (ER), and HER2 pathways.
  • Curcumin regulates apoptosis and cell phase-related genes and microRNA.

Conclusions:

  • Curcumin demonstrates significant anticancer and chemoprevention potential in breast cancer.
  • Its mechanisms involve intricate molecular signaling pathways.
  • Further research into curcumin's targets and mechanisms is warranted.