Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

7.9K
7.9K
Telomeres and Telomerase02:41

Telomeres and Telomerase

28.3K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
28.3K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.6K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.4K
3.4K
Aging01:26

Aging

967
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
967
Replication in Eukaryotes01:29

Replication in Eukaryotes

18.8K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
18.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

XPC and global genome nucleotide excision repair are essential for telomere stability after UVC-induced DNA damage in human cells.

DNA repair·2026
Same author

ARNT2 repression disrupts neuronal identity and promotes glioblastoma growth.

Cell communication and signaling : CCS·2026
Same author

Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer.

Immunity·2026
Same author

Epigenetic consequences of DNA damage.

Molecular cell·2026
Same author

Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition.

Cancer research·2026
Same author

Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex.

Nature communications·2025

Related Experiment Video

Updated: Mar 20, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.8K

Telomere-associated aging disorders.

Patricia L Opresko1, Jerry W Shay2

  • 1University of Pittsburgh, Department of Environmental and Occupational Health, and University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, United States.

Ageing Research Reviews
|May 25, 2016
PubMed
Summary
This summary is machine-generated.

Telomere shortening causes telomeropathies, a spectrum of premature aging diseases. This review covers primary and secondary telomeropathies, exploring disease mechanisms and future therapeutic strategies.

Keywords:
Premature agingRecQ helicasesTelomeraseTelomere

More Related Videos

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.5K
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.9K

Related Experiment Videos

Last Updated: Mar 20, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.8K
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.5K
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.9K

Area of Science:

  • Genetics and Molecular Biology
  • Cell Biology
  • Aging Research

Background:

  • Telomeres are protective DNA-protein structures at chromosome ends.
  • Telomeropathies are inherited diseases linked to shortened telomeres, causing premature aging.
  • These disorders share mechanisms but show variable symptoms and onset ages.

Purpose of the Study:

  • To review primary and secondary telomeropathies.
  • To discuss mechanisms behind tissue specificity and age of onset.
  • To highlight research gaps and future therapeutic directions.

Main Methods:

  • Literature review of primary and secondary telomeropathies.
  • Analysis of genetic defects in telomere maintenance and DNA repair.
  • Discussion of pathogenetic mechanisms and clinical variability.

Main Results:

  • Primary telomeropathies stem from telomere maintenance defects.
  • Secondary telomeropathies involve DNA repair protein mutations impacting telomere length.
  • Both types exhibit overlapping symptoms but differ in primary cause.

Conclusions:

  • Telomeropathies represent a spectrum of aging disorders due to telomere dysfunction.
  • Understanding tissue specificity and age of onset is crucial.
  • Further research is needed for effective therapeutic strategies.