Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulse rhythm01:30

Pulse rhythm

1.6K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.6K
Pulse Assessment Sites01:11

Pulse Assessment Sites

3.2K
Pulse assessment sites are crucial in evaluating a patient's cardiovascular health. By assessing the pulsations of arteries at specific anatomical locations, healthcare professionals can gather valuable information about blood flow, heart rate, and peripheral circulation. Understanding these pulse assessment sites is essential for conducting comprehensive cardiovascular evaluations and monitoring patients' overall health. These sites are strategically chosen due to the accessibility and...
3.2K
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

606
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
606
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

1.0K
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
1.0K
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

1.2K
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
1.2K
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

1.8K
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atrial Fibrillation in Diabetes: Epidemiology, Mechanisms and Integrated Management.

Journal of clinical medicine·2026
Same author

Correction: A novel thermochromic myocardial phantom for radiofrequency ablation and cryoablation.

Scientific reports·2026
Same author

Inflammasome-Driven Cardiac Fibrosis in Cardiometabolic Disease and Arrhythmias: Mechanisms, Biomarkers, and Therapeutic Targets.

Frontiers in bioscience (Landmark edition)·2026
Same author

Simultaneous Transvenous Lead Extraction and Intra-Operative Epicardial Extravascular Defibrillator (EV-ICD) Implantation During Tricuspid Valve Replacement.

Clinical case reports·2026
Same author

Cardiac Arrhythmias: Advances in Mechanisms, Diagnosis, and Treatment.

Life (Basel, Switzerland)·2026
Same author

Flecainide in Structural Heart Disease: Reconsidering Its Role in Contemporary Arrhythmia Management.

Life (Basel, Switzerland)·2026

Related Experiment Video

Updated: Mar 20, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K

Multisite Pacing for Cardiac Resynchronization Therapy: Promise and Pitfalls.

Antonios P Antoniadis1, Jonathan M Behar2, Simon Claridge2

  • 1Cardiovascular Department, Guy's and St Thomas' NHS Foundation Trust, 6th Floor East Wing, St Thomas' Hospital, Westminster Bridge Road, SE1 7EH, London, UK. aantoniadis@gmail.com.

Current Cardiology Reports
|May 25, 2016
PubMed
Summary

Multisite pacing (MSP) using multipolar leads may improve cardiac resynchronization therapy (CRT) outcomes for heart failure patients who do not respond to traditional CRT. Further research is needed to optimize settings and confirm benefits.

Keywords:
Biventricular pacingCardiac resynchronization therapyDyssynchronyHeart failureMultipolar left ventricular leadsMultisite pacing

More Related Videos

Translational Rabbit Model of Chronic Cardiac Pacing
06:14

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

3.2K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

2.1K

Related Experiment Videos

Last Updated: Mar 20, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K
Translational Rabbit Model of Chronic Cardiac Pacing
06:14

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

3.2K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

2.1K

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Cardiac resynchronization therapy (CRT) is used for heart failure patients with conduction delays, but outcomes vary, with up to 33% being non-responders.
  • Multisite pacing (MSP) is being explored to enhance CRT efficacy by stimulating the heart from multiple locations.

Purpose of the Study:

  • To investigate the potential of multisite pacing (MSP) as an alternative or adjunct to traditional CRT.
  • To explore the use of multipolar left ventricular leads for achieving MSP with a single lead.

Main Methods:

  • The study discusses the concept of MSP, contrasting traditional methods requiring multiple leads with newer approaches using multipolar LV leads.
  • Challenges such as increased battery drain and generator replacements with traditional MSP are highlighted.

Main Results:

  • The hypothesis suggests that increasing pacing sites in the left ventricle can lead to more coordinated myocardial contraction.
  • Multipolar leads offer a single-lead solution for MSP, potentially mitigating issues associated with multiple leads.

Conclusions:

  • Multisite pacing via multipolar leads presents a promising strategy for improving CRT response rates in heart failure patients.
  • Optimal programming and clinical outcomes of this single-lead MSP approach require further investigation.