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Related Concept Videos

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Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
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Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
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Mood, stress and longevity: convergence on ANK3.

S Rangaraju1, D F Levey2, K Nho3

  • 1Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Molecular Psychiatry
|May 25, 2016
PubMed
Summary

Antidepressant treatment in worms revealed ANK3 as a key gene influencing longevity and stress response. This finding suggests ANK3 may be a target for interventions to promote healthy aging and mood regulation in humans.

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Area of Science:

  • Genetics and Aging Research
  • Neuroscience and Pharmacology

Background:

  • Antidepressants have demonstrated lifespan-extending properties in model organisms like C. elegans.
  • The underlying biological mechanisms linking mood regulation, stress response, and longevity are not fully understood.

Purpose of the Study:

  • To elucidate the molecular pathways connecting antidepressant action with longevity.
  • To identify genes involved in mood regulation and stress that also influence aging.
  • To validate the role of candidate genes, particularly ANK3, in both model organisms and humans.

Main Methods:

  • Transcriptome analysis of C. elegans treated with the antidepressant mianserin.
  • Genome-wide association study (GWAS) in humans to identify genes associated with depressive symptoms.
  • Convergent functional genomics (CFG) to prioritize genes for mood disorders and stress.
  • Genetic and gene-expression studies in C. elegans (mutants and wild-type) and human cohorts.

Main Results:

  • Mianserin treatment altered gene expression in pathways related to drug metabolism (nicotine, melatonin).
  • The gene ANK3 was identified as a top candidate linking mood, stress, and longevity.
  • ANK3 inactivation in C. elegans increased lifespan, especially in older worms, and was necessary for mianserin's longevity effects.
  • Human genetic studies showed a trend towards longer lifespan in men carrying a risk allele for depressive symptoms in ANK3.
  • ANK3 expression levels correlated with biological age in human cohorts, with altered patterns in psychiatric patients and suicide completers.

Conclusions:

  • ANK3 plays a significant role in aging and longevity, potentially through antagonistic pleiotropy.
  • ANK3 and related genes represent novel biological links between mood, stress, and aging processes.
  • These findings highlight ANK3 as a potential biomarker for biological age and a target for interventions promoting healthy aging.