Related Experiment Video

Updated: Mar 20, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.8K

Safety and Efficacy of Permacol Injection in the Treatment of Fecal Incontinence

Yahya A Al-Abed1, Jennifer Ayers1, Abraham Ayantunde1

  • 1Department of Colorectal Surgery, Southend University Hospital, Westcliff on Sea, United Kingdom.

Annals of Coloproctology
|May 25, 2016
PubMed
Abstract

Insights

Permacol injections offer a safe and effective treatment for fecal incontinence (FI), significantly improving patient quality of life. While initial results are promising, repeat injections may be necessary for sustained symptom relief.

Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Medical Device Technology

Background:

  • Fecal incontinence (FI) significantly impacts quality of life.
  • Permacol injection is an emerging treatment option for FI.
  • Evaluating novel therapeutic approaches for FI is crucial.

Purpose of the Study:

  • To assess the safety and efficacy of anal submucosal Permacol injection for treating fecal incontinence.
  • To determine the long-term outcomes and patient satisfaction following Permacol injection therapy.

Main Methods:

  • A retrospective study included patients undergoing Permacol injection for FI over three years.
  • Data collected included patient demographics, FI type, anorectal physiology, and follow-up outcomes.
  • Cleveland Clinic Florida Incontinence Scores (CCFIS) and telephone surveys were used to evaluate efficacy and quality of life.

Main Results:

  • Thirty patients (28 female, 2 male; median age 67) with various FI types were included.
  • Significant improvement in CCFIS (P < 0.001) was observed post-injection.
  • 89% of surveyed patients reported satisfaction with symptom improvement and overall experience.

Conclusions:

  • Permacol injection is a safe and effective treatment for fecal incontinence with no major complications.
  • While initial responses are positive, the effects may not be permanent, necessitating repeat injections in some patients.
  • Permacol offers a viable option for managing fecal incontinence, improving patient outcomes and satisfaction.
Keywords:
Anal bulking agentFecal incontinencePermacol injection

More Related Videos

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

2.1K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.5K

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.2K
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
853
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
602
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
824
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
1.5K