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Updated: Mar 20, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Roles of FGFR in oral carcinogenesis

Xiaoyan Xie1, Zhiyong Wang1, Fangman Chen1

  • 1State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, China.

Cell Proliferation
|May 25, 2016
PubMed

Insights

Altered Fibroblast Growth Factor Receptor (FGFR) signaling drives oral squamous cell carcinoma (OSCC) development. Targeting FGFRs offers promising anti-cancer strategies for OSCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Fibroblast Growth Factor Receptors (FGFRs) are crucial for embryonic development and adult tissue repair.
  • Aberrant FGFR signaling is implicated in various cancers.
  • Oral Squamous Cell Carcinoma (OSCC) pathogenesis involves complex molecular alterations.

Purpose of the Study:

  • To review the aberrant regulation of FGFRs in OSCC.
  • To elucidate the oncogenic roles of FGFRs and their downstream pathways in OSCC.
  • To discuss FGFR-targeted therapies for OSCC.

Main Methods:

  • Literature review focusing on FGFRs in OSCC.
  • Analysis of altered FGFR expression, splicing, and mutations in OSCC.
  • Overview of FGFR signaling pathways and their impact on OSCC progression.

Main Results:

  • FGFR alterations, including expression changes, aberrant splicing, and mutations, are key in OSCC pathogenesis.
  • FGFR signaling promotes OSCC cell proliferation and metastasis.
  • Specific FGFRs and their downstream pathways contribute to oncogenesis.

Conclusions:

  • Aberrant FGFR signaling is a critical driver of OSCC.
  • FGFRs represent viable therapeutic targets for OSCC.
  • Targeting FGFRs holds potential for preclinical and clinical anti-cancer strategies in OSCC.

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